This study aims to explore the incidence and risk factors for developing postoperative pulmonary complications after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy and to analyze how these complications affect overall survival.ĭata were collected on 417 patients undergoing surgery between 2007 and2017 at Uppsala University Hospital, Sweden. All surgeons pursuing this specialty should perform a regular audit of their results, irrespective of their experience.Įxtensive abdominal surgery is associated with the risk of postoperative pulmonary complications. Systemic sepsis, spontaneous bowel perforations, and pulmonary complications increased the risk of FTR and multidisciplinary teams should develop protocols to prevent, identify, and effectively treat such complications. Nearly one-fifth of the patients who developed complications succumbed to them. The primary tumor site did not have an impact on the FTR rate (p = 0.09) or on the grade 3–4 morbidity (p = 0.08). The independent predictors were spontaneous bowel perforation (p = 0.05) and systemic sepsis (p = 0.001) and PCI > 20 (p = 0.02). Pulmonary complications (p = 0.03), systemic sepsis (p 20 (p = 0.002) increased the risk of failure-to-rescue. Twenty-five (6.6%) patients died within 90 days of surgery due to complications. The most common complications were pulmonary complications (6.8%), neutropenia (3.7%), systemic sepsis (3.4%), anastomotic leaks (1.5%), and spontaneous bowel perforations (1.3%). The median PCI was 11 and a CC-0/1 resection was achieved in 353 (93.5%). Three hundred seventy-eight patients undergoing CRS with/without HIPEC for peritoneal metastases from various primary sites, between January 2013 and December 2017 were included.
The 30- and 90-day morbidity were both recorded.
Complications were graded according to the CTCAE classification version 4.3. A retrospective analysis of patients enrolled in the Indian HIPEC registry was performed. To determine factors influencing failure-to-rescue in patients with complications following cytoreductive surgery and HIPEC.
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